Illness handicapped him. 疾病使他处于不利地位
He was obviously handicapped by lack of experience. 他显然是因为缺乏经验而吃亏.

Although he was short-sighted, he worked hard to overcome this handicap as a soldier. 为了成为一个合格的士兵,他努力克服近视眼这一障碍
Nowadays not being able to use a computer is quite a handicap for a secretary. 今天的秘书如不会使用电脑,那是很吃亏的.